The Role of CXCL12 in Kidney Diseases: A Friend or Foe?

The Role of CXCL12 in Kidney Diseases: A Friend or Foe?

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Background: Chemokines are a family of proteins mainly mediating the homing and migration of various cells.The CXC chemokine CXCL12 is a member of low-weight-molecular chemokines.In the kidney, CXCL12 is pivotal for renal development and exerts a modulatory effect in kidney diseases under different etiologic settings by binding with CXC chemokine receptor 4 (CXCR4) or CXC chemokine receptor 7 (CXCR7).Besides, CXCL12 also exerts homeostasis influence in diverse physical conditions and various pathological situations.

Thus, we conclude the east genesis hybrid dump trailer complicated relationship between CXCL12 and kidney diseases in this review.Summary: In renal development, CXCL12 contributes a lot to nephrogenesis and the formation of renal vasculature via correlating with CXCR4.CXCL12 also plays an essential role in renal recovery from acute kidney injury.However, the CXCL12/CXCR4 axis plays a dual regulatory role in the initiation and development of diabetic kidney disease as well as chronic allogeneic nephropathy after kidney transplantation through dialectical consideration.

Additionally, the CXCL12/CXCR4 link is considered as a new risk factor for lupus nephritis and renal cell carcinoma.Key Messages: eyevan 163 Plenty of studies have presented the influence of CXCL12 and the relation with corresponding receptors in diverse biological and pathological statuses.Simultaneously, some drugs and antagonists targeting CXCL12/CXCR4 axis effectively treat various kidney diseases.However, more researches are needed to explore thorough influence and mechanisms, providing more cues for clinical treatments.